In recent years, science has increasingly turned the spotlight on one particular molecule: spermidine. Indeed, this natural compound seems to have beneficial effects on the body, so much so that it has earned the title “longevity molecule.” But what exactly is spermidine and how can it affect the body’s health and well-being? We talked about it with Dr. Laura Mazzotta, a specialist in Hygiene and Preventive Medicine, Clinical Nutrition and Aesthetic Medicine in Ferrara, Italy
1) What is spermidine?
Spermidine is a polyamine, a class of organic compounds found naturally in the cells of all living things. Its name comes from the fact that it was first discovered in human seminal fluid, but today we know that it is widely distributed in various tissues and organs. Its main function is to support cell growth, protein synthesis and cell renewal, processes that are essential for the proper functioning of the body
2) Why is it called the “longevity molecule”?
Spermidine is considered a key molecule for longevity because of its ability to stimulateautophagy, a biological process by which cells degrade and recycle damaged or unused components. This mechanism, so important that it earned Yoshinori Ohsumi the Nobel Prize in Medicine in 2016, helps keep cells young and functional, preventing premature aging and reducing the risk of neurodegenerative disease, cardiovascular disease, and even some types of cancer.Scientific studies have shown that higher spermidine intake improves cellular health and reduces oxidative stress, all in favor of the body’s longevity
3) What foods contain it?
Fortunately, spermidine is present in numerous foods commonly brought to the table. Among the main sources of spermidine, next to wheat germ oil, which is the richest in it but should be taken as a supplement, we can list: – legumes particularly peas and soybeans, with all their derivatives – whole grains, particularly brown rice and oats, millet and amaranth – aged cheeses, parmesan, grana and pecorino, which should always be introduced, however, in controlled doses – mushrooms– green leafy vegetables, such as spinach and broccoli– fruits, particularly pears, apples and citrus fruits.
Following a diet rich in these foods can help maintain good levels of spermidine in the body and promote its beneficial effects. As conversely dietary imbalances and improper diets are likely to cause the body to lack the valuable supply of this molecule
4) Can a supplement be useful?
Interest in spermidine has led to the creation of specific supplements, which are especially useful in those who have difficulty taking sufficient amounts through the diet. Studies suggest that supplementation may be beneficial in slowing cellular aging and improving cognitive and cardiac function, especially in old age when natural spermidine production is reduced. However, it is critical to rely on certified products and to consult a physician before starting to take them, to assess dosages and possible interactions with other medications
5) Topically, how does it perform?
In addition to food and supplemental use, spermidine is also gaining popularity in cosmetics. Applied topically, it is being studied for its potential anti-aging effect on skin and hair. Indeed, it appears that it may stimulate the production of collagen and elastin, the elastic fibers that give support to the skin, helping to improve skin tone and reduce the formation of wrinkles and sagging. In addition, some studies suggest it may promote hair growth, making it an interesting ingredient in shampoos and treatments specifically for hair loss
6) Can it also serve gynecological purposes?
A 2013 Italian study showed that spermidine, combined with other larger molecules such as hyaluronic acid, improves tissue trophism in the female intimate area. It is therefore effective, applied topically, in treating vaginal dryness but also in reducing pain in the presence of conditions such as vestibulodynia.